Jeffery L. Platt

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Jeffrey L. Platt, M.D.

Professor of Surgery, Immunology, and Pediatrics

Director, Transplantation Biology, Mayo Clinic

platt.jeffrey@mayo.edu

http://www.mayo.edu/pediatrics-rst/staff-jlp.html
 

Xenotransplantation and Immunology
Cancer Center Research - Immunology Program
Division of Nephrology
Immunology
Pediatric and Adolescent Medicine
Surgical Research
Transplantation Biology
Ph.D. Program in Basic Immunology

 

Published Materials

Xenotransplantation: Basic Research and Clinical Applications

ISBN: 089603674X Humana Press, 1st edition, May 15, 2002, 270 pages

Xenotransplantation

ISBN: 1555811671 Amer. Society for Microbiology, 1st edition ,January 15, 2001, 298 pages
 

PubMED

1995

McCurry K., Kooyman D.L., Diamond L., Byrne G., Logan J. and J.L. Platt (1995). "Transgenic expression of human complement regulatory proteins on mice results in diminished complement disposition during organ xenoperfusion." Transplantation. 27; 59(8): p. 1177-82.

McCurry K., Kooyman D.L., Alvarado C.G., Cotterell A.H., Martin M.J., Logan J.S. and J.L. Platt (1995). "Human complement regulatory proteins protect swine to primate cardiac xenografts from humoral injury." Nature Medicine. 1(5): p. 423-7.
 

1997

Byrne, G.W., McCurry, K.R., Martin, M.J., McClellen, S.M., Platt, J.L. and J.S. Logan (1997). Transgenic pigs expressing human CD59 and DAF produce an intrinsic barrier to complement mediated damage." Transplantation 15; 63(1): p. 149-55.

1998

Lin SS, Weidner BC, Byrne GW, Diamond LE, Lawson JH, Hoopes CW, Daniels LJ, Daggett CW, Parker W, Harland RC, Davis RD, Bollinger RR, Logan JS, Platt JL. (1998) The role of antibodies in acute vascular rejection of pig-to-baboon cardiac transplants. J Clin Invest 15; 101(8): p. 1745-56.

Platt JL. (1998) New directions for organ transplantation. Nature 30; 392(6679 Suppl): p. 11-7.
 

Kalady MF, Lawson JH, Sorrell RD, Platt JL. (1998) Decreased fibrinolytic activity in porcine-to-primate cardiac xenotransplantation. Mol Med. 4(9): p. 629-37.

1999

Yu PB, Parker W, Everett ML, Fox IJ, Platt JL. (1999) Immunochemical properties of anti-Gala-3Gal after sensitization. J Clin Immunol. 19(2): p. 116-26.

Platt, JL., (1999) Prospects for xenotransplantation. [Review] Pediatr Transplant. 3(3): p. 193-200.

2000

Kanazawa, A. Platt, JL., (2000) Prospects for xenotransplantation of the liver [Review], Semin Liver Dis 20(4): p. 511-22.

Lin, SS. Hanaway, MJ. Gonzalez-Stawinski, G. Lau, CL. Parker, W. Davis, RD. Byrne, GW. Diamond, LE. Logan, JS. Platt, JL., (2000) The role of anti-Gal alpha 1-3Gal antibodies in acute vascular rejection and accomodation of xenografts, Transplantation 27; 70(12): p. 1667-74.

Platt, JL., (2000) "Xenoassistance devices" for the treatment of hepatic failure: Challenges and controversies, Transplant Proc 32(8): p. 2693-5.

Platt, JL., (2000) Zoonosis in xenotransplantation, Transplant Proc 32(7): p. 1551.

Platt, JL., (2000) Physiologic barriers to xenotransplantation, Transplant Proc 32(7): p. 1547-8.

Holzknecht, ZE. Coombes, S. Blocher, BA. Plummer, TB. Bustos, M. Lau, CL. Davis, RD. Platt, JL., (2000) Evidence of immunocomplex formation in pulmonary xenografts, Transplant Proc 32(5): p. 1141.

Holzknecht, ZE. Williams, JM. Plummer, TB. Platt, JL., (2000) Apoptosis in acute vascular rejection of xenografts, Transplant Proc 32(5): p. 973.

Platt, JL., (2000) Xenotransplantation - New risks, new gains, Nature. 7;407(6800): p. 27, 29-30.

Kanai, N. Platt, JL., (2000) Xenotransplantation of the Liver.,Clinics in Liver Disease. [Review] Clin Liver Dis. 4(3): p. 731-46, x-xi.

Lau, CL. Daggett, WC. Yeatman, MF. Chai, P. Lin, SS. Lodge, AJ. Chen, EP. Diamond, LE. Byrne, GW. Logan, JS. Parker, W. Platt, JL. Davis, RD., (2000) The role of antibodies in dysfunction of pig-to-baboon pulmonary transplants, J Thorac Cardiovasc Surg. 120(1): p. 29-38.

Nyberg, SL. Hibbs, JR. Hardin, JA. Germer, JJ. Platt, JL. Paya, CV. Wiesner, RH., (2000) Influence of human fulminant hepatic failure sera on endogenous retroviral expression in pig hepatocytes, Liver Transpl. 6(1): p. 76-84.

Nagayasu, T. Saadi, S. Holzknecht, RA. Plummer, TB. Platt, JL., (2000) Expression of tissue factor mRNA in cardiac xenografts - Clues to the pathogenesis of acute vascular rejection, Transplantation. 27;69(4): p. 475-82.

Foley, DP. Collins, BR. Magee, JC. Platt, JL. Katz, E. Harland, RC. Meyers, WC. Chari, RS., (2000) Bile acids in xenogeneic ex-vivo liver perfusion - Function of xenoperfused livers and compatibility with human bile salts and porcine livers, Transplantation. 27;69(2): p. 242-8.

2001

Parker, W. Stitzenberg, KB. Yu, PB. Pratt, VSW. Nakamura, YC. Farel, LS. Ward, CM. Lin, SS. Everett, ML. Platt, JL., (2001) Biophysical characteristics of anti-Gal alpha 1-3Gal IgM binding to cell surfaces: Implications for xenotransplantation, Transplantation 15;71(3): p. 440-6.

Holzknecht, ZE. Coombes, S. Blocher, BA. Plummer, TB. Bustos, M. Lau, CL. Davis, RD. Platt, JL., (2001) Immune complex formation after xenotransplantation - Evidence of type III as well as type II immune reactions provide clues to pathophysiology, Am J Pathol. 158(2): p. 627-37.

Samstein, B. Platt, JL., (2001) Physiologic and immunologic hurdles to xenotransplantation [Review], J Am Soc Nephrol. 12(1): p. 182-93.

Bustos M, Platt J L. (2001) The pathology of cardiac xenografts. J Card Surg 16(5): p. 357-62

Platt JL. (2001) The immunological hurdles to cardiac xenotransplantation. J Card Surg 16(6): p. 439-47

2002

Platt JL, Ogle BM. (2002) Genetic therapies and xenotransplantation. Expert Opin Biol Ther 2(3): p. 299-310

Platt JL.(2002) Knocking out xenograft rejection. Nat Biotechnol 20(3): p. 231-2

 

 

 

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